NSC 207895

Names

[ Name ]:
NSC 207895

[Synonym ]:
7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazan 1-oxide
Benzofurazan,4-(4-methyl-1-piperazinyl)-7-nitro-,3-oxide
7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide
B2368
2,1,3-Benzoxadiazole, 7-(4-methyl-1-piperazinyl)-4-nitro-, 1-oxide
7-(4-Methylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazole 1-oxide

Biological Activity

[Description]:

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> MDM-2/p53

[In Vitro]

NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels[2]. NSC-207895, MDMX inhibitor, downregulates the expression of MDMX in AML cells at the mRNA and protein levels[3]. Western Blot Analysis[2] Cell Line: RAW 264.7 cells. Concentration: 0.5 μM. Incubation Time: 30 min (stimulated with LPS (100 ng/ml) for 6 h). Result: Upregulated p53 protein levels.

[References]

[1]. Laura Kapitzky, et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.

[2]. Erdenezaya Odkhuu, et al. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015 Jan;220(1):136-41.

[3]. Luis A Carvajal, et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 Apr 11;10(436):eaao3003.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
487.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₃N₅O₄

[ Molecular Weight ]:
279.252

[ Flash Point ]:
248.7±31.5 °C

[ Exact Mass ]:
279.096741

[ PSA ]:
103.79000

[ LogP ]:
1.46

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.738

[ Storage condition ]:
-20℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF8029000

CHEMICAL NAME :: Benzofurazan, 7-(4-methyl-1-piperazinyl)-4-nitro-, 1-oxide

CAS REGISTRY NUMBER :: 58131-57-0

LAST UPDATED :: 199410

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H13-N5-O4

MOLECULAR WEIGHT :: 279.29

WISWESSER LINE NOTATION :: T56 BNONJ BO FNW I- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,3735,1975