H9M2E
Names
[ CAS No. ]:
58337-35-2
[ Name ]:
H9M2E
[Synonym ]:
ELLIPTINIUM ACETATE
Ellipticine acetomethylate
9-hydroxy-2-methylellipticinium acetate
elliptinium
Elliptinii acetas [INN-Latin]
EINECS 261-216-0
Acetato de eliptinio [INN-Spanish]
Acetate d'elliptinium [INN-French]
Celiptium
9-hydroxy-N-2-methylellipticinium acetate
Elliptinium acetate [INN:BAN]
N2-Methylhydroxyellipticinium acetate
N2-methyl-9-hydroxyellipticinium acetate
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Nucleic acids[1][2].
[In Vitro]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H20N2O3
[ Molecular Weight ]:
336.38400
[ Exact Mass ]:
336.14700
[ PSA ]:
80.03000
[ LogP ]:
2.37740
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UU8875500
- CHEMICAL NAME :
- 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-2,5,11-trimethyl-, acetate
- CAS REGISTRY NUMBER :
- 58337-35-2
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C18-H17-N2-O.C2-H3-O2
- MOLECULAR WEIGHT :
- 336.42
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 mg/kg/8W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 89,281,1987