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Cucurbitacin IIA

Names

[ CAS No. ]:
58546-34-2

[ Name ]:
Cucurbitacin IIA

[Synonym ]:
23,24-Dihydrocucurbitacin F-25-O-acetate
19-Norlanost-5-ene-11,22-dione, 25-(acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-
Curcurbitacin Q1
(1S,2S,4R,9β,16α)-1,2,16,20-Tetrahydroxy-9,10,14-trimethyl-11,22-dioxo-4,9-cyclo-9,10-secocholest-5-en-25-yl acetate
Estr-5-en-11-one, 17-[(1R)-5-(acetyloxy)-1-hydroxy-1,5-dimethyl-2-oxohexyl]-2,3,16-trihydroxy-4,4,9,14-tetramethyl-, (2β,3α,9β,10α,16α,17β)-
Dihydrocucurbitacin F 25-O-acetate
X1160
Dihydrocucurbitacin Q1
25-O-Acetyl-23,24-dihydrocucurbitacin F
Cucurbitacin IIa
Hemslecin A

Biological Activity

[Description]:

Cucurbitacin IIa is a triterpene isolated from Hemsleya amalils Diels, induces apoptosis of cancer cells, reduces expression of survivin, reduces phospho-Histone H3 and increases cleaved PARP in cancer cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Survivin

[References]

[1]. Boykin C, et al. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation. Br J Cancer. 2011 Mar 1;104(5):781-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
679.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H50O8

[ Molecular Weight ]:
562.735

[ Flash Point ]:
209.7±25.0 °C

[ Exact Mass ]:
562.350586

[ PSA ]:
141.36000

[ LogP ]:
2.82

[ Vapour Pressure ]:
0.0±4.8 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
N

Related Compounds