Meranzin hydrate

Names

[ Name ]:
Meranzin hydrate

[Synonym ]:
2H-1-Benzopyran-2-one, 8-[(2S)-2,3-dihydroxy-3-methylbutyl]-7-methoxy-
8-(2,3-Dihydroxy-3-methylbutyl)-7-methoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 8-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-
8-[(2S)-2,3-Dihydroxy-3-methylbutyl]-7-methoxy-2H-chromen-2-one

Biological Activity

[Description]:

Meranzin hydrate, an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS), possess anti-depression and anti-atherosclerosis effects[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Huang X, et al. Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from Chaihu-Shugan-San. PLoS One. 2014 Nov 26;9(11):e113819.

[2]. Li L, et al. Chaihu-Shugan-San and absorbed meranzin hydrate induce anti-atherosclerosis and behavioral improvements in high-fat diet ApoE-/- mice via anti-inflammatory and BDNF-TrkB pathway. Biomed Pharmacother. 2019 Jul;115:108893.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
500.5±50.0 °C at 760 mmHg

[ Melting Point ]:
130-131°C

[ Molecular Formula ]:
C₁₅H₁₈O₅

[ Molecular Weight ]:
278.300

[ Flash Point ]:
188.3±23.6 °C

[ Exact Mass ]:
278.115417

[ PSA ]:
79.90000

[ LogP ]:
0.61

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.580

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ Hazard Codes ]:
N

[ Risk Phrases ]:
50

[ Safety Phrases ]:
61

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Searching the cytochrome p450 enzymes for the metabolism of meranzin hydrate: a prospective antidepressant originating from Chaihu-Shugan-San.

PLoS ONE 9(11) , e113819, (2014)

Meranzin hydrate (MH), an absorbed bioactive compound from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS), was first isolated in our laboratory and was found to possess anti-depression...