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H-Val-Pro-Pro-OH

Names

[ CAS No. ]:
58872-39-2

[ Name ]:
H-Val-Pro-Pro-OH

[Synonym ]:
Val-pro-pro
V-P-P
L-valyl-L-prolyl-L-proline
L-Proline,L-valyl-L-prolyl
L-Val-L-Pro-L-Pro
H-VAL-PRO-PRO-OH

Biological Activity

[Description]:

H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
Research Areas >> Metabolic Disease

[Target]

IC50: 9 μM (ACE)[1].


[In Vitro]

H-Val-Pro-Pro-OH, a proline peptides derivative, could inhibit Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM[1]. H-Val-Pro-Pro-OH could enhance insulin sensitivity and prevent insulin resistance in 3T3-F442A pre-adipocytes. H-Val-Pro-Pro-OH also has anti-hypertensive and anti-inflammatory functions. H-Val-Pro-Pro-OH further enhances the expression of glucose transporter 4 (GLUT4) in adipocytes and restores glucose uptake in TNF-treated adipocytes[2].

[References]

[1]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

[2]. Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187.

Chemical & Physical Properties

[ Density]:
1.275 g/cm3

[ Boiling Point ]:
566.446ºC at 760 mmHg

[ Molecular Formula ]:
C15H25N3O4

[ Molecular Weight ]:
311.38

[ Flash Point ]:
296.376ºC

[ Exact Mass ]:
311.18500

[ PSA ]:
103.94000

[ LogP ]:
0.61240

[ Storage condition ]:
2-8℃

Related Compounds