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Albaspidin AP

Names

[ CAS No. ]:
59092-91-0

[ Name ]:
Albaspidin AP

[Synonym ]:
1,7-dichloro-2,6-bis(chloro(difluoro)methyl)-1,1,7,7-tetrafluoro-2,6-dihydroxy-4-heptanone oxime
4-Heptanone, 2,6-bis(chlorodifluoromethyl)-1,7-dichloro-2,6-dihydroxy-1,1,7,7-tetrafluoro-, oxime
1,7-Dichloro-2,6-bis[chloro(difluoro)methyl]-1,1,7,7-tetrafluoro-4-(hydroxyimino)-2,6-heptanediol
4-Heptanone, 1,7-dichloro-2,6-bis(chlorodifluoromethyl)-1,1,7,7-tetrafluoro-2,6-dihydroxy-, oxime
Albaspidin AP

Biological Activity

[Description]:

Albaspidin AP inhibits fatty acid synthase (FAS) with an IC50 value of 71.7 μM. Fatty acid synthase (FAS) is emerging as a potential therapeutic target for cancer and obesity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
Research Areas >> Metabolic Disease

[References]

[1]. MinKyun Na, et al. Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4738-42.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
434.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H7Cl4F8NO3

[ Molecular Weight ]:
470.956

[ Flash Point ]:
216.5±28.7 °C

[ Exact Mass ]:
468.905243

[ LogP ]:
10.44

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.439

Related Compounds