<Suppliers Price>

Aloenin aglycone

Names

[ CAS No. ]:
59163-53-0

[ Name ]:
Aloenin aglycone

[Synonym ]:
4-methoxy-6-(2',4'-dihydroxy-6'-methylphenyl)pyran-2-one
Aloenin-Aglycon
6-(2',4'-dihydroxy-6'-methylphenyl)-4-methoxy-2-pyrone
6-(2,4-dihydroxy-6-methyl-phenyl)-4-methoxy-pyran-2-one
2H-Pyran-2-one,6-(2,4-dihydroxy-6-methylphenyl)-4-methoxy
aloenin aglycone

Biological Activity

[Description]:

Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[Target]

intercellular adhesion molecule-1 (ICAM-1)[1]


[References]

[1]. Sun Y N, et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.

[2]. Sun Y N. et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H12O5

[ Molecular Weight ]:
248.23100

[ Exact Mass ]:
248.06800

[ PSA ]:
79.90000

[ LogP ]:
2.03500

Synthetic Route

Click to get detail synthetic route

Related Compounds