Bis-acrylate-PEG5

Names

[ Name ]:
Bis-acrylate-PEG5

[Synonym ]:
EINECS 261-677-8
16-oxo-3,6,9,12,15-pentaoxaoctadec-17-en-1-yl acrylate
3,6,9,12-Tetraoxatetradecane-1,14-diyl diacrylate

Biological Activity

[Description]:

Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.098g/cm3

[ Boiling Point ]:
421.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₆O₈

[ Molecular Weight ]:
346.37300

[ Flash Point ]:
181.9ºC

[ Exact Mass ]:
346.16300

[ PSA ]:
89.52000

[ LogP ]:
0.51120

[ Index of Refraction ]:
1.458

Bis-acrylate-PEG5

Names

Biological Activity

Chemical & Physical Properties

Related Compounds