Exisulind

Names

[ Name ]:
Exisulind

[Synonym ]:
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfonylphenyl)methylidene]inden-1-yl]acetic acid
Sulindac Sulfone

Biological Activity

[Description]:

Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

[References]

[1]. Aono Y, et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun. 2018 Nov 10;505(4):1203-1210.

Chemical & Physical Properties

[ Melting Point ]:
248-250ºC

[ Molecular Formula ]:
C₂₀H₁₇FO₄S

[ Molecular Weight ]:
372.41

[ Exact Mass ]:
372.08300

[ PSA ]:
79.82000

[ LogP ]:
5.11240

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Exisulind

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds