Creatinine

Names

[ CAS No. ]:
60-27-5

[ Name ]:
Creatinine

[Synonym ]:
Creatinine,heated
Creatinine
1-Methylglycocyamidine
4H-Imidazol-4-one,2-amino-1,5-dihydro-1-methyl
2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one
[3H]-Creatinine
2-amino-1-methylimidazolin-4-one
2-amino-3-methyl-4H-imidazol-5-one
2-Amino-1-methyl-1,5-dihydroimidazol-4-one
1-methyl-2-amino-1,5-dihydroimidazol-4-one
EINECS 200-466-7
MFCD00059730
1-Methylhydantoin-2-imide
2-Amino-1-methyl-1,5-dihydro-4H-imidazol-4-one
[14C]-Creatinine
4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-methyl-
2-imino-1-methylimidazolidin-4-one
2-Imino-N-methylhydantoin

Biological Activity

[Description]:

Creatinine(NSC13123) is a break-down product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body.Target: OthersCreatinine is a breakdown product of creatine phosphate in muscle, and is usually produced at a fairly constant rate by the body (depending on muscle mass). Creatine is synthesized primarily in the liver from the methylation of glycocyamine (guanidino acetate, synthesized in the kidney from the amino acids arginine and glycine) by S-adenosyl methionine. It is then transported through blood to the other organs, muscle, and brain, where, through phosphorylation, it becomes the high-energy compound phosphocreatine. During the reaction, creatine and phosphocreatine are catalyzed by creatine kinase, and a spontaneous conversion to creatinine may occur [1]. Creatinine levels in blood and urine may be used to calculate the creatinine clearance (CrCl), which reflects the glomerular filtration rate (GFR), an important clinical index of renal function [2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Natural Products >> Alkaloid

[Target]

Human Endogenous Metabolite

[References]

[1]. Allen, P.J., Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value. Neurosci Biobehav Rev, 2012. 36(5): p. 1442-62.

[2]. Levey, A.S., et al., Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med, 2006. 145(4): p. 247-54.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
184.3±23.0 °C at 760 mmHg

[ Melting Point ]:
295 °C (dec.)(lit.)

[ Molecular Formula ]:
C₄H₇N₃O

[ Molecular Weight ]:
113.118

[ Flash Point ]:
65.3±22.6 °C

[ Exact Mass ]:
113.058914

[ PSA ]:
58.69000

[ LogP ]:
-1.68

[ Vapour Pressure ]:
0.2±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
SOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25

[ RIDADR ]:
UN 1789 8/PG 3

[ WGK Germany ]:
3

[ HS Code ]:
2933290090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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