Spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trione,7-hydroxy-3',6,7,14-tetramethyl-, (1R,2'R,3'R,6R,7R)-
Names
[ CAS No. ]:
60102-37-6
[ Name ]:
Spiro[2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-4,2'-oxirane]-3,8,17-trione,7-hydroxy-3',6,7,14-tetramethyl-, (1R,2'R,3'R,6R,7R)-
[Synonym ]:
(15R,20R)-15,20-Epoxy-15,20-dihydro-12-hydroxy-4-methyl-4,8-secosenecionan-8,11,16-trione
Otosenin,Othosenin
Petasitenine
PETASITINENE
Chemical & Physical Properties
[ Density]:
1.29g/cm3
[ Boiling Point ]:
614.7ºC at 760 mmHg
[ Molecular Formula ]:
C19H27NO7
[ Molecular Weight ]:
381.42000
[ Flash Point ]:
325.6ºC
[ Exact Mass ]:
381.17900
[ PSA ]:
105.67000
[ LogP ]:
0.15860
[ Index of Refraction ]:
1.557
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SE5085000
- CHEMICAL NAME :
- Petasitenine
- CAS REGISTRY NUMBER :
- 60102-37-6
- LAST UPDATED :
- 199510
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C19-H27-N-O7
- MOLECULAR WEIGHT :
- 381.47
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 921 mg/kg/13W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,3125,1985 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,207,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,207,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW PPTCBY Proceedings of the International Symposium of the Princess Takamatsu Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku, Tokyo 113, Japan) 1st- 1971- Volume(issue)/page/year: 9,79,1979
Safety Information
[ RIDADR ]:
UN 1544
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)