ANB-NOS

Names

[ Name ]:
ANB-NOS

[Synonym ]:
1-[(5-Azido-2-nitrobenzoyl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(5-azido-2-nitrobenzoyl)oxy]-
2,5-Pyrrolidinedione, 1-((5-azido-2-nitrobenzoyl)oxy)-
(2,5-dioxopyrrolidin-1-yl) 5-azido-2-nitrobenzoate

Biological Activity

[Description]:

ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Melting Point ]:
131-133ºC

[ Molecular Formula ]:
C₁₁H₇N₅O₆

[ Molecular Weight ]:
305.203

[ Exact Mass ]:
305.039642

[ PSA ]:
159.25000

[ LogP ]:
0.53

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2.

Biochemistry 16 , 5650-5654, (1977)

Two novel heterobifunctional cross-linking reagents, which can be used to attach photoactivatable nitroaryl azides to primary amino groups of proteins, have been synthesized. The two compounds, N-5-az...

Covalent binding of biological samples to solid supports for scanning probe microscopy in buffer solution.

Biophys. J. 65(6) , 2437-46, (1993)

Scanning force microscopy allows imaging of biological molecules in their native state in buffer solution. To this end samples have to be fixed to a flat solid support so that they cannot be displaced...

[Structural characterization of the somatostatin receptors on rat cerebrocortical membranes].

Nihon Naibunpi Gakkai Zasshi 66(10) , 1108-16, (1990)

We characterized structurally the receptors for somatostatin in rat cerebral cortex by affinity labeling with [125I-Tyr1] somatostatin. [125I-Tyr1] somatostatin was cross-linked to cerebrocortical mem...