<Suppliers Price>

Methyldopate

Names

[ CAS No. ]:
6014-30-8

[ Name ]:
Methyldopate

[Synonym ]:
Ethyl 3-hydroxy-α-methyl-L-tyrosinate
Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, ethyl ester, L-
L-Methyldopa ethyl ester
3-Hydroxy-a-methyl-L-tyrosine Ethyl Ester
MFCD00865839
L-3-(3,4-Dihydroxyphenyl)-2-methylalanine ethyl ester
EINECS 219-720-3
2579Z4P04J
L-Tyrosine, 3-hydroxy-α-methyl-, ethyl ester
EINECS 219-821-2
Methyldopate
L-Methyldopate

Biological Activity

[Description]:

Methyldopate is an ethyl ester prodrug of α-Methyldopa (α-MD; HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate has the potential for severe hypertension research [1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[In Vivo]

Methyldopate is hydrolysed in vivo to methyldopa[2].

[References]

[1]. P D Walson, et al. Metabolic disposition and cardiovascular effects of methyldopate in unanesthetized rhesus monkeys. J Pharmacol Exp Ther. 1975 Oct;195(1):151-8.

[2]. Hoskins JA, et al. Determination of alpha-methyldopa and methyldopate in human breast milk and plasma by ion-exchange chromatography using electrochemical detection. J Chromatogr. 1982 Jun 11;230(1):162-7.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
398.0±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H17NO4

[ Molecular Weight ]:
239.268

[ Flash Point ]:
194.5±26.5 °C

[ Exact Mass ]:
239.115753

[ LogP ]:
0.81

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.573

Related Compounds