THP-PEG3-OH

Names

[ Name ]:
THP-PEG3-OH

[Synonym ]:
2-{2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethanol
8-(2H-tetrahydropyran-2-yloxy)-3n36-dioxaoctan-1-ol
8-(1H-tetrahydropyran-2-yloxy)-3n63-dioxaoctan-1-ol
Ethanol,2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]

Biological Activity

[Description]:

THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂O₅

[ Molecular Weight ]:
234.28900

[ Exact Mass ]:
234.14700

[ PSA ]:
57.15000

[ LogP ]:
0.55510

THP-PEG3-OH

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Related Compounds