Hordenine hydrochloride

Names

[ Name ]:
Hordenine hydrochloride

[Synonym ]:
4-[2-(Dimethylamino)ethyl]phenol hydrochloride (1:1)
Hordenine HCl
Eremursine hydrochloride
Anhaline hydrochloride
Phenol, 4-[2-(dimethylamino)ethyl]-, hydrochloride (1:1)
Peyocactine hydrochloride
p-Hordenine hydrochloride
hordenine hydrochloride
Hordenin*HCl
EINECS 227-892-6
N,N-Dimethyltyramine hydrochloride
MFCD00040807
Hordeninhydrochlorid

Biological Activity

[Description]:

Hordenine (hydrochloride), an alkaloid found in?plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. R C Howe, et al. Cactus alkaloids. XXXIV. Hordenine HCL from Coryphantha vivipara var. arizonica. 1Planta Med. 1997, 37, 3.

Chemical & Physical Properties

[ Boiling Point ]:
270.2ºC at 760 mmHg

[ Melting Point ]:
178 °C

[ Molecular Formula ]:
C₁₀H₁₆ClNO

[ Molecular Weight ]:
201.693

[ Flash Point ]:
123.5ºC

[ Exact Mass ]:
201.092041

[ PSA ]:
23.47000

[ LogP ]:
2.29830

[ Storage condition ]:
2~8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL1225000

CHEMICAL NAME :: Phenol, p-(2-(dimethylamino)ethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 6027-23-2

LAST UPDATED :: 199103

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H15-N-O.Cl-H

MOLECULAR WEIGHT :: 201.72

WISWESSER LINE NOTATION :: QR D2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 114 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,750,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCSOA9 Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see JCPRB4. Volume(issue)/page/year: -,191,1947

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%