Guanabenz

Names

[ CAS No. ]:
60329-03-5

[ Name ]:
Guanabenz

Biological Activity

[Description]:

(E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Research Areas >> Neurological Disease

[Target]

α2-adrenoceptor, GADD34[1][2]


[References]

[1]. Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107.

[2]. Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331.

Chemical & Physical Properties

[ Molecular Formula ]:
C8H8Cl2N4

[ Molecular Weight ]:
231.08200

[ Exact Mass ]:
230.01300

[ PSA ]:
76.76000

[ LogP ]:
3.00130

Precursor & DownStream

Precursor

DownStream

Related Compounds