6-Iodoamiloride

Names

[ Name ]:
6-Iodoamiloride

[Synonym ]:
3,5-diamino-6-iodo-pyrazine-2-carboxylic acid carbamimidoylamide
N-Amidino-3,5-diamino-6-iodo-2-pyrazinecarboxamide
6-Iodoamiloride

Biological Activity

[Description]:

6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Cancer

Research Areas >> Neurological Disease

[Target]

IC50: 88 nM (ASIC1)[1]

[References]

[1]. Rocio K Finol-Urdaneta, et al. Automated Patch Clamp Screening of Amiloride and 5- N, N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 Jul 3;20(7):3367-3379.

Chemical & Physical Properties

[ Density]:
2.74g/cm3

[ Boiling Point ]:
657.5ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₈IN₇O

[ Molecular Weight ]:
321.08

[ Flash Point ]:
351.4ºC

[ Exact Mass ]:
320.98400

[ PSA ]:
160.28000

[ LogP ]:
1.40610

[ Index of Refraction ]:
1.988

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%