TY-51469
Names
[ CAS No. ]:
603987-59-3
[ Name ]:
TY-51469
Biological Activity
[Description]:
TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
[Related Catalog]:
[Target]
IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1]
[In Vivo]
TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2].
[Animal admin]
Rats[1] The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1]. Mice[1] the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2].
[References]
[Related Small Molecules]
Captisol
|
Cyclosporin A
|
H2DCFDA
|
0MPTP hydrochloride
|
GW4869
|
Etomoxir
|
TD139
|
Mitoquinone mesylate
|
GSK2795039
|
JC-1
|
BAPTA-AM
|
AP 20187
|
Setanaxib (GKT137831)
|
D-Luciferin
|
Crotaline
Chemical & Physical Properties
[ Molecular Formula ]:
C20H15FN2O6S4
[ Molecular Weight ]:
526.60