7,8-Benzoflavone

Names

[ CAS No. ]:
604-59-1

[ Name ]:
7,8-Benzoflavone

[Synonym ]:
Benzo[h]flavone
2-phenylbenzo[h]chromen-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-phenyl-
α-Naphthylflavone
2-Phenyl-4H-benzo[h]chromen-4-one
2-Phenylbenzo(h)chromen-4-one
a-Naphthylflavone
2-Phenyl-benzo[h]chromen-4-one
alpha-naphthoflavone
7,8-Benzoflavone
MFCD00004985
a-Naphthoflavone
α-Naphthoflavone
2-Phenyl-4H-naphtho[1,2-b]pyran-4-one
EINECS 210-071-1

Biological Activity

[Description]:

Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Aromatase

[Target]

IC50: 0.5 μM (Aromatase)[1] Ki: 0.2 μM (Aromatase)[1]

[References]

[1]. Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
460.9±45.0 °C at 760 mmHg

[ Melting Point ]:
153-157 °C(lit.)

[ Molecular Formula ]:
C₁₉H₁₂O₂

[ Molecular Weight ]:
272.297

[ Flash Point ]:
215.8±22.3 °C

[ Exact Mass ]:
272.083740

[ PSA ]:
30.21000

[ LogP ]:
4.79

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.695

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL6250000

CHEMICAL NAME :: 4H-Naphtho(1,2-b)pyran-4-one, 2-phenyl-

CAS REGISTRY NUMBER :: 604-59-1

BEILSTEIN REFERENCE NO. :: 0210862

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H12-O2

MOLECULAR WEIGHT :: 272.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 40 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,3662,1987

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,Xn,C,F

[ Risk Phrases ]:
68-34-11

[ Safety Phrases ]:
S24/25-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL6250000

[ HS Code ]:
2914399090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail.

Anal. Bioanal. Chem 406(18) , 4453-64, (2014)

Knowledge about the cytochrome P450 (CYP) inhibition potential of new drug candidates is important for drug development because of its risk of interactions. For novel psychoactive substances (NPS), co...

In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach.

Arch. Toxicol. 90 , 305-18, (2016)

In vitro cytochrome P450 (CYP) inhibition assays are common approaches for testing the inhibition potential of drugs for predicting potential interactions. In contrast to marketed medicaments, drugs o...

Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

Toxicol. Lett. 241 , 82-94, (2015)

New psychoactive substances (NPS) are not tested for their cytochrome P450 (CYP) inhibition potential before consumption. Therefore, this potential was explored for tryptamine-derived NPS (TDNPS) incl...