Ald-Ph-NHS ester

Names

[ Name ]:
Ald-Ph-NHS ester

[Synonym ]:
Benzaldehyde, 4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]-
(2,5-dioxopyrrolidin-1-yl) 4-formylbenzoate
4-{[(2,5-Dioxo-1-pyrrolidinyl)oxy]carbonyl}benzaldehyde

Biological Activity

[Description]:

Ald-Ph-NHS ester is a nonclaevable linker for antibody-drug-conjugation (ADC).

[Related Catalog]:

Research Areas >> Cancer

[Target]

Noncleavable

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
425.4±47.0 °C at 760 mmHg

[ Melting Point ]:
163ºC

[ Molecular Formula ]:
C₁₂H₉NO₅

[ Molecular Weight ]:
247.204

[ Flash Point ]:
211.1±29.3 °C

[ Exact Mass ]:
247.048065

[ PSA ]:
80.75000

[ LogP ]:
-0.20

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.606

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

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Metastatic prostate cancer causes significant morbidity and mortality and there is a critical unmet need for effective treatments. We have developed a theranostic nanoplex platform for combined imagin...

A strategy for the systematic development of a liquid chromatographic mass spectrometric screening method for polymer electrolyte membrane degradation products using isocratic and gradient phase optimized liquid chromatography.

J. Chromatogr. A. 1216 , 8910-8917, (2009)

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Synthesis of pH-sensitive amphotericin B-poly(ethylene glycol) conjugates and study of their controlled release in vitro.

Bioorg. Med. Chem. 15 , 4069-4076, (2007)

New intravenous conjugates of amphotericin B (AMB) with poly(ethylene glycols) (PEG) (M=5000, 10,000, 20,000) have been synthesized and characterised. The intermediate PEGs possess a 1,4-disubstituted...