DCEBIO

Names

[ Name ]:
DCEBIO

[Synonym ]:
5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one
5,6-dichloro-1-ethyl-1,3-dihydro-benzoimidazol-2-one
DC-EBIO
5,6-dichloro-3-ethyl benzimidazolone
5,6-Dichlor-1-ethyl-benzimidazolon
5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
5,6-dichloro-1-ethyl-benzimidazolinone
Tocris-1422
5,6-Dichlor-2-oxo-1-ethyl-benzimidazolin
dichloro-EBIO

Biological Activity

[Description]:

DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

Cl－ secretion[1]

[References]

[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.

[2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.

Chemical & Physical Properties

[ Density]:
1.413g/cm3

[ Melting Point ]:
209.5-210.5 °C

[ Molecular Formula ]:
C₉H₈Cl₂N₂O

[ Molecular Weight ]:
231.08

[ Exact Mass ]:
230.00100

[ PSA ]:
37.79000

[ LogP ]:
2.65630

[ Index of Refraction ]:
1.592

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels in Human Glioma Cells.

Cell Physiol. Biochem. 37 , 1390-406, (2015)

Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels ...

Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells.

Respir. Res. 10 , 120, (2009)

Secondhand smoke (SHS) exposure is an independent risk factor for asthma, rhinosinusitis, and more severe respiratory tract infections in children and adults. Impaired mucociliary clearance with subse...