Pamabrom

Names

[ CAS No. ]:
606-04-2

[ Name ]:
Pamabrom

[Synonym ]:
Predema
2-amino-2-methylpropanol 8-bromotheophyllinate
Premsyn PMS
EINECS 210-103-4
Pamabrom|
MFCD00867328
8-bromo-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
8-Brom-1,3-dimethyl-3,7-dihydro-purin-2,6-dion,Verbindung mit 2-Amino-2-methyl-propan-1-ol
8-bromo-1,3-dimethyl-3,7-dihydro-purine-2,6-dione,compound with 2-amino-2-methyl-propan-1-ol
UNII-UA8U0KJM72
Sunril
Pamabrom

Biological Activity

[Description]:

Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms. The active diuretic ingredient in pamabrom is 8-bromotheophylline. Pamabrom is available in combination with acetaminophen (paracetamol) for various conditions such as back pain and menstrual relief. The acetaminophen helps reduce menstrual pains and the pamabrom reduces associated bloating.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[References]

[1]. Ortiz MI, Rangel-Flores E, Carrillo-Alarcón LC, et al. Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009 Dec;107(3):240-3.

[2]. Swanson JK, English JC 3rd. Serum sickness-like reaction to Pamabrom. J Drugs Dermatol. 2006 Mar;5(3):284-6.

[3]. Di Girolamo G, Sánchez AJ, De Los Santos AR, et al. Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? Expert Opin Pharmacother. 2004 Mar;5(3):561-70.

[4]. Pamabrom

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
469.5ºC at 760 mmHg

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₁₁H₁₈BrN₅O₃

[ Molecular Weight ]:
348.19600

[ Flash Point ]:
237.7ºC

[ Exact Mass ]:
347.05900

[ PSA ]:
118.93000

[ LogP ]:
0.13910

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Articles

Serum sickness-like reaction to Pamabrom.

Journal. of. Drugs in. Dermatology. 5(3) , 284-6, (2006)

Pamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms. An urticarial eruption, with systemic complaints consistent with a serum sickness-like reaction, attrib...

Fixed drug eruption from pamabrom.

Cleve. Clin. J. Med. 58(1) , 33-4, (1991)

A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual sy...

Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment.

Eur. J. Obstet. Gynecol. Reprod. Biol. 152(1) , 73-7, (2010)

To evaluate the prevalence, impact and treatment of primary dysmenorrhea among Mexican university students.A multiple-choice questionnaire was administered to 1539 students in six university programs:...