4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

Names

[ Name ]:
4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid

[Synonym ]:
EINECS 262-509-6
Benzoic acid, 4-(4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)-
MFCD00003135
1-(4-Carboxylphenyl)-3-methyl-5-pyrazolone
4-(3-Methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoicacid

Biological Activity

[Description]:

4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid has hypoglycaemic activity. 4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid follows a mechanism based on the response to the oral glucose overcharge[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. G M Antón-Fos, et al. Pharmacological Studies of the Two New Hypoglycaemic Compounds 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic Acid and 1-(mesitylen-2-sulfonyl)-1H-1,2,4-triazole. Arzneimittelforschung. 1994 Jul;44(7):821-6.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
477.6±28.0 °C at 760 mmHg

[ Melting Point ]:
285 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₁H₁₀N₂O₃

[ Molecular Weight ]:
218.209

[ Flash Point ]:
242.7±24.0 °C

[ Exact Mass ]:
218.069138

[ PSA ]:
69.97000

[ LogP ]:
0.11

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.642

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pharmacological studies of the two new hypoglycaemic compounds 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid and 1-(mesitylen-2-sulfonyl)-1H-1,2,4-triazole.

Arzneimittelforschung 44(7) , 821-6, (1994)

New compounds showing hypoglycaemic activity have been designed through a computer-aided method based on QSAR (quantitative structure activity relationship) and molecular connectivity. The pharmacolog...