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Triolein-d5

Names

[ CAS No. ]:
60892-83-3

[ Name ]:
Triolein-d5

[Synonym ]:
9-Octadecenoic acid, 1,2,3-propanetriyl-d5 ester, (9Z,9'Z,9''Z)-
(2H5)-1,2,3-Propanetriyl (9Z,9'Z,9''Z)tris(-9-octadecenoate)

Biological Activity

[Description]:

Triolein-d5 is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Leirós GJ, et al. Triolein reduces MMP-1 upregulation in dermal fibroblasts generated by ROS production in UVB-irradiated keratinocytes. J Dermatol Sci. 2017 Feb;85(2):124-130.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
818.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C57H99D5O6

[ Molecular Weight ]:
890.46

[ Flash Point ]:
302.7±31.5 °C

[ Exact Mass ]:
889.814697

[ LogP ]:
23.71

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.477

Related Compounds