Tanshinone IIA anhydride

Names

[ CAS No. ]:
61077-78-9

[ Name ]:
Tanshinone IIA anhydride

Biological Activity

[Description]:

Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with Ki values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

Ki: 1.9 nM (Human carboxylesterase (CE)) and 1.4 nM (human intestinal CE)[1]


[References]

[1]. M Jason Hatfield, et al. Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen"). J Nat Prod. 2018 Nov 26;81(11):2410-2418.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H18O4

[ Molecular Weight ]:
310.34

Related Compounds