(S,E)-Ethyl 2,5-Dimethyl-4-(Methylamino)Hex-2-Enoate Hydrochloride

Names

[ Name ]:
(S,E)-Ethyl 2,5-Dimethyl-4-(Methylamino)Hex-2-Enoate Hydrochloride

[Synonym ]:
Ethyl (2E,4S)-2,5-dimethyl-4-(methylamino)-2-hexenoate hydrochloride (1:1)
MFCD29472351
2-Hexenoic acid, 2,5-dimethyl-4-(methylamino)-, ethyl ester, (2E,4S)-, hydrochloride (1:1)

Biological Activity

[Description]:

Taltobulin intermediate-3 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂ClNO₂

[ Molecular Weight ]:
235.75

[ Exact Mass ]:
235.133911