1-Methyl-2-nitrosobenzene

Names

[ CAS No. ]:
611-23-4

[ Name ]:
1-Methyl-2-nitrosobenzene

[Synonym ]:
2-Methyl-1-nitrosobenzene
o-Nitrosotoluene
1-Methyl-2-nitrosobenzene
Benzene,1-methyl-2-nitroso
Benzene, 1-methyl-2-nitroso-
MFCD00002061
2-methyl-nitrosobenzene
TOLUENE,o-NITROSO
2-nitrosotoluene
ortho-nitrosotoluene
o-methyl-nitrosobenzene
EINECS 210-261-4

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
199.9±19.0 °C at 760 mmHg

[ Melting Point ]:
72-75 °C(lit.)

[ Molecular Formula ]:
C₇H₇NO

[ Molecular Weight ]:
121.137

[ Flash Point ]:
74.7±26.8 °C

[ Exact Mass ]:
121.052765

[ PSA ]:
29.43000

[ LogP ]:
2.47

[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.524

[ Storage condition ]:
0-6°C

[ Stability ]:
Stable. Incompatible with oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT3400000

CHEMICAL NAME :: Toluene, o-nitroso-

CAS REGISTRY NUMBER :: 611-23-4

BEILSTEIN REFERENCE NO. :: 1927295

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H7-N-O

MOLECULAR WEIGHT :: 121.15

WISWESSER LINE NOTATION :: ONR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 103 gm/kg/73W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 umol/plate

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,618,1987

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN1759

[ WGK Germany ]:
3

[ RTECS ]:
XT3400000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

Synthetic Route

Click to get detail synthetic route

Articles

Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes.

Arch. Biochem. Biophys. 436(2) , 265-75, (2005)

The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring l...

Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine.

Arch. Biochem. Biophys. 372(1) , 97-106, (1999)

Mechanisms of DNA damage by metabolites of carcinogenic o-toluidine in the presence of metals were investigated by the DNA sequencing technique using (32)P-labeled human DNA fragments. 4-Amino-3-methy...

Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats.

Cancer Lett. 16(1) , 103-8, (1982)

o-Toluidine hydrochloride and one of its metabolites, o-nitrosotoluene, were administered in the diet (0.028 mol/kg diet) to 2 groups of 30 male F-344 rats for 72 weeks. o-Nitrosotoluene induced signi...