Quinine sulfate dihydrate

Names

[ Name ]:
Quinine sulfate dihydrate

[Synonym ]:
Hydrogen sulfate - (8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1:2:2)
Hydrogen sulfate (8α,9R)-6'-methoxycinchonan-9-ol hydrate (2:1:2:2)
EINECS 212-359-2
Quinine Sulfate Dihydrate
(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol,sulfuric acid,dihydrate
Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, sulfate, hydrate (2:1:2) (salt)
MFCD00150790

Biological Activity

[Description]:

Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25.

[2]. Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.

[3]. Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44

Chemical & Physical Properties

[ Boiling Point ]:
495.9ºC at 760 mmHg

[ Melting Point ]:
233-235ºC

[ Molecular Formula ]:
C₂₀H₃₀N₂O₈S

[ Molecular Weight ]:
458.53

[ Flash Point ]:
253.7ºC

[ Exact Mass ]:
782.356079

[ PSA ]:
192.62000

[ LogP ]:
6.52160

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R42/43

[ Safety Phrases ]:
S24-S37-S45

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
VA8440000

[ HS Code ]:
29392000

Customs

[ HS Code ]: 29392000