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O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride

Names

[ CAS No. ]:
6138-47-2

[ Name ]:
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride

[Synonym ]:
Liothyronine hydrochloride
trionine
Liothyronine HCl
Thyrotradin (TN)
EINECS 228-120-0

Biological Activity

[Description]:

Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Endocrinology
Signaling Pathways >> Others >> Thyroid Hormone Receptor

[Target]

Human Endogenous Metabolite


[In Vitro]

Liothyronine (T3, 100 nM) hydrochloride stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. Liothyronine hydrochloride binds to human β1 thyroid hormone receptor (hTRβ1), and changes its conformation. Liothyronine hydrochloride promotes growth, induces differentiation and regualtes metabolic effects[2].

[References]

[1]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94.

[2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.

[3]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H13ClI3NO4

[ Molecular Weight ]:
687.43400

[ Exact Mass ]:
686.76700

[ PSA ]:
92.78000

[ LogP ]:
5.45500

Related Compounds