Closantel Sodium

Names

[ Name ]:
Closantel Sodium

[Synonym ]:
EINECS 262-794-7
MFCD03427328
Sodium 2-({5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}carbamoyl)-1-hydroxy-4,6-diiodo-2,4-cyclohexadiene-1-carboxylate
2,4-Cyclohexadiene-1-carboxylic acid, 2-[[[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]amino]carbonyl]-1-hydroxy-4,6-diiodo-, sodium salt (1:1)
Closantel (sodium)

Biological Activity

[Description]:

Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[References]

[1]. Bacon JA, et al. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8.

[2]. Macielag MJ, et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998 Jul 30;41(16):2939-45.

[3]. Waruiru RM. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet Parasitol. 1997 Dec 15;73(1-2):65-71.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
590.5ºC at 760 mmHg

[ Melting Point ]:
>230ºC (dec.)

[ Molecular Formula ]:
C₂₂H₁₃Cl₂I₂N₂NaO₂

[ Molecular Weight ]:
685.06

[ Flash Point ]:
310.9ºC

[ PSA ]:
113.25000

[ LogP ]:
4.51228

[ Storage condition ]:
Refrigerator

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2926909090

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%