(±)-Vasicine

Names

[ Name ]:
(±)-Vasicine

[Synonym ]:
Pyrrolo[2,1-b]quinazolin-3-ol, 1,2,3,9-tetrahydro-, (3R)-
(3S)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
(R)-1,2,3,9-Tetrahydropyrrolo(2,1-b)quinazolin-3-ol
1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
(3R)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol
Vasicine

Biological Activity

[Description]:

(±)-Vasicine is the racemate of Vasicine. Vasicine (Peganine), isolated from Peganum harmala seeds, significantly inhibits H+-K+-ATPase activity in vitro with an IC50 of 73.47 μg/mL. Anti-ulcer activity. Vasicine shows significant anti-secretory, antioxidant and cytoprotective effect[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

[In Vitro]

Vasicine (Peganine) exhibits strong antioxidant activity in the DPPH inhibition assay with an IC50 value of 71.97±3.79 μg/mL[1].

[References]

[1]. Singh VK, et al. Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers.Phytomedicine. 2013 Oct 15;20(13):1180-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
373.8±52.0 °C at 760 mmHg

[ Melting Point ]:
211 °C

[ Molecular Formula ]:
C₁₁H₁₂N₂O

[ Molecular Weight ]:
188.226

[ Flash Point ]:
179.9±30.7 °C

[ Exact Mass ]:
188.094955

[ PSA ]:
35.83000

[ LogP ]:
-1.00

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.709

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(±)​-​Vasicine