Ethoxylated hydrogenated castor oil

Names

[ Name ]:
Ethoxylated hydrogenated castor oil

[Synonym ]:
Brotopon
Einalon S
Eukystol
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
Peluces
Haldol
Halosten
Linton
Aloperidin
4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone
Sigaperidol
Butyrophenone, 4-[4- (p-chlorophenyl)-4-hydroxypiperidino]-4'-fluoro-
haloperidol
Haloperidol [USAN:BAN:INN:JAN]
1-Butanone, 4-[4- (4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-
1-Butanone, 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Serenace
4-[4-(4-Chlorphenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorphenyl)butan-1-on
Bioperidolo
Dozic
Keselan

Biological Activity

[Description]:

Ethoxylated hydrogenated castor oil (PEG-40 hydrogenated castor oil) is a combination of synthetic polyethylene glycol (PEG) with natural castor oil. Ethoxylated hydrogenated castor oil can be used to emulsify and solubilize oil-in-water (o/w) emulsions. Ethoxylated hydrogenated castor oil can be used as a cosolvent in vivo[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vivo]

20% PEG-40 hydrogenated castor oil (10 μl) is applied to the left ear of the mouse, and the right ear served as a control. The mice are observed for development of erthyma for 6 days, no signs of irritation are observed in the mice[1]. PEG-40 hydrogenated castor oil (injection via the tail vein; 300, 900, and 2700 mg/kg; 4 weeks) is administared for short-term toxicity. At doses of 300 and 900 mg/kg PEG-40 Hydrogenated Castor Oi exhibits no systemic toxicity. However, at a dose of 2700 mg/kg, slight ataxia is observed and body weight is reduced significantly in the males and slightly in the females[1]. A toxicity study of blank nanoemulsion using PEG-40 hydrogenated castor oil as a surfactant is applied in order to load various active compounds for oral administration[2]. Nearly 20% of PEG-40 hydrogenated castor oil was used to emulsify the glyceryl monooleate (GMO) as an oil to the aqueous phase. In Webster mice, 5000 mg/kg blank nanoemulsion is given orally to mice once a day for 14 days, this nanoemulsion does not produce hazardous effects, and it has no effect on food intake[2].

[References]

[1]. PEG-40 HYDROGENATED CASTOR OIL

[2]. Heni Rachmawati, et al. The In Vitro-In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm. 2017 Mar 31;85(2):18. doi: 10.3390/scipharm85020018.

[3]. PEGylated Oils as Used in Cosmetics

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
529.0±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₃ClFNO₂

[ Molecular Weight ]:
375.864

[ Flash Point ]:
273.8±30.1 °C

[ Exact Mass ]:
375.140137

[ LogP ]:
3.01

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

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Arch. Pharm. Res. 30(1) , 82-9, (2007)

Silymarin has been used to treat hepatobiliary diseases. However, it has a low bioavailability after being administered orally on account of its low solubility in water. In order to improve the dissol...

Preparation and evaluation of self-nanoemulsifying tablets of carvedilol.

AAPS PharmSciTech 10(1) , 183-92, (2009)

The purpose of this study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form emphasizing the excipients' effect on the development of...

Detailed molecular characterization of castor oil ethoxylates by liquid chromatography multistage mass spectrometry.

J. Chromatogr. A. 1218(40) , 7166-72, (2011)

The molecular characterization of castor oil ethoxylates (CASEOs) was studied by reverse-phase liquid chromatography (RPLC) mass spectrometry (MS) and multistage mass spectrometry (MS(n)). The develop...