Methacholine (chloride)

Names

[ CAS No. ]:
62-51-1

[ Name ]:
Methacholine (chloride)

[Synonym ]:
Methacholinium chloride
Besacholine
Mechothane
1-propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride
Methacholine chloride
β-Methylcholine chloride urethan
Urecholine chloride
Uro-Carb
2-carbamoyloxypropyl(trimethyl)azanium,chloride
b-Methylacetylcholine Chloride
Acetyl-b-methylcholine Chloride
2-Acetoxy-N,N,N-trimethylpropan-1-aminium chloride
(2-Carbamoyloxy-propyl)-trimethyl-ammonium,Chlorid
2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium chloride
Carbamate of (2-Hydroxypropyl)trimethylammonium Chloride
Mictone
2-(acetyloxy)-N,N,N-trimethylpropan-1-aminium chloride
2-(Carbamoyloxy)-N,N,N-trimethyl-1-propanaminium chloride
2-[(aminocarbonyl)oxy]-N,N,N-trimethylpropan-1-aminium chloride
Carbamylmethylcholine chloride
Urecholine
2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium Chloride
(2-Carbamoyloxypropyl)trimethylammonium chloride
2-acetyloxypropyl(trimethyl)azanium,chloride
Bethanechol chloride
(2-carbamoyloxy-propyl)-trimethyl-ammonium,chloride
Trimethyl-b-acetoxypropylammonium Chloride
EINECS 200-537-2
Mechotane
O-Acetyl-b-methylcholine Chloride
BTC
Mecothane
2-carbamyloxy-1-(N,N,N-trimethyl)-propylammonium chloride
1-Propanaminium, 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl-, chloride (1:1)
methylcarbachol chloride
UNII:0W5ETF9M2K
Bethanechol
1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1)
DUVOID
Myocholine
2-Acetoxy-N,N,N-trimethyl-1-propanaminium chloride
MFCD00011817
(±)-Acetyl-b-methylcholine Chloride
Methacholine (chloride)

Biological Activity

[Description]:

Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mAChR

Signaling Pathways >> Neuronal Signaling >> mAChR

Research Areas >> Others

[References]

[1]. Birnbaum S, et al. Methacholine challenge testing: identifying its diagnostic role, testing, coding, and reimbursement. Chest. 2007 Jun;131(6):1932-5.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1028 (rough estimate)

[ Melting Point ]:
171-173ºC(lit.)

[ Molecular Formula ]:
C₈H₁₈ClNO₂

[ Molecular Weight ]:
195.687

[ Exact Mass ]:
195.102600

[ PSA ]:
26.30000

[ Index of Refraction ]:
1.5790 (estimate)

[ Stability ]:
Unstable - moisture sensitive. Incompatible with oxidizing agents.

[ Water Solubility ]:
H2O: 50 mg/mL, clear, colorless | almost transparency

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BR5250000

CHEMICAL NAME :: Ammonium, (2-hydroxypropyl)trimethyl-, chloride, acetate

CAS REGISTRY NUMBER :: 62-51-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C8-H18-N-O2.Cl

MOLECULAR WEIGHT :: 195.72

WISWESSER LINE NOTATION :: 1VOY1&1K1&1&1 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 22,210,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3750 ug/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,245,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2961 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 307 (estimated) No. of Female Employees: 162 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BR5250000

[ HS Code ]:
29239000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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