PD 407824
Names
Biological Activity
[Description]:
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2].
[Related Catalog]:
[Target]
Chk1:47 nM (IC50)
WEE1:97 nM (IC50)
[In Vitro]
PD 407824 is sufficient to block CHK1, leading to a significant down-regulation of p21, causing activation of CDK8/9, which in turn causes depletion of SMAD2/3[1]. PD 407824 is selective for Chk1 and WEE1 over PKC and Cdk4 with IC50s of 3.4 µM and 3.75 µM, respectively[3].
[References]
Chemical & Physical Properties
[ Density]:
1.507g/cm3
[ Molecular Formula ]:
C20H12N2O3
[ Molecular Weight ]:
328.32100
[ Exact Mass ]:
328.08500
[ PSA ]:
85.95000
[ LogP ]:
3.33320
[ Index of Refraction ]:
1.81
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ RIDADR ]:
NONH for all modes of transport