FORMAMIDOXIME

Names

[ CAS No. ]:
624-82-8

[ Name ]:
FORMAMIDOXIME

[Synonym ]:
EINECS 210-865-8
carboxamidoxime
Aminoformaldehyde oxime
formamideoxime
N-hydroxycarboximidamide
n-hydroxy-methanimidamid
formamidoxim
n-hydroxymethanimidamide
isuretin
MFCD00008125
isouretin

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
224ºC at 760 mmHg

[ Melting Point ]:
112-115ºC(lit.)

[ Molecular Formula ]:
CH₄N₂O

[ Molecular Weight ]:
60.05530

[ Flash Point ]:
89.3ºC

[ Exact Mass ]:
60.03240

[ PSA ]:
58.61000

[ LogP ]:
0.06290

[ Index of Refraction ]:
1.471

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ4632000

CHEMICAL NAME :: Formamidoxime

CAS REGISTRY NUMBER :: 624-82-8

LAST UPDATED :: 199304

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C-H4-N2-O

MOLECULAR WEIGHT :: 60.07

WISWESSER LINE NOTATION :: QM1UM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-40

[ Safety Phrases ]:
22-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LQ4632000

[ HS Code ]:
2925290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Antitumor activity of amidoximes (hydroxyurea analogs) in murine tumor systems.

Cancer Res. 38(5) , 1291-5, (1978)

A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-am...

Nitric oxide synthesis by tracheal smooth muscle cells by a nitric oxide synthase-independent pathway.

Am. J. Physiol. 275(5 Pt 1) , L895-901, (1998)

Nitric oxide (NO) is known to be synthesized from L-arginine in a reaction catalyzed by NO synthase. Liver cytochrome P-450 enzymes also catalyze the oxidative cleavage of C==N bonds of compounds cont...

Effects of phenobarbital, beta-naphthoflavone, dexamethasone, and formamidoxime on the turnover of inducible microsomal proteins in cultured hepatocytes.

J. Biol. Chem. 256(24) , 13079-84, (1981)

Microsomal proteins from cultured chick embryo hepatocytes were separated by polyacrylamide gel electrophoresis and their rate constants of degradation (Kd) were estimated using double isotope techniq...