Hydroxychloroquine Impurity F

Names

[ Name ]:
Hydroxychloroquine Impurity F

[Synonym ]:
nx 357
4-(2-Methyl-1-Pyrrolidyl)-7-Chloroquinoline
Plaquenil Impurity 2

Biological Activity

[Description]:

Hydroxychloroquine Impurity F is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

[2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

[3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

Chemical & Physical Properties

[ Density]:
1.214g/cm3

[ Boiling Point ]:
392.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₅ClN₂

[ Molecular Weight ]:
246.73500

[ Flash Point ]:
191.2ºC

[ Exact Mass ]:
246.09200

[ PSA ]:
16.13000

[ LogP ]:
3.94190

[ Index of Refraction ]:
1.626

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VB3329000

CHEMICAL NAME :: Quinoline, 7-chloro-4-(2-methylpyrrolidinyl)-

CAS REGISTRY NUMBER :: 6281-58-9

BEILSTEIN REFERENCE NO. :: 0203557

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H15-Cl-N2

MOLECULAR WEIGHT :: 246.76

WISWESSER LINE NOTATION :: T66 BNJ IG E- AT5NTJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00357