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KM-233

Names

[ CAS No. ]:
628263-22-9

[ Name ]:
KM-233

[Synonym ]:
KM-233
6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-(1-methyl-1-phenylethyl)-, (6aR,10aR)-
(6aR,10aR)-6,6,9-Trimethyl-3-(2-phenyl-2-propanyl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

Biological Activity

[Description]:

KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[References]

[1]. Duntsch C, et al. Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma. J Neurooncol. 2006 Apr;77(2):143-52.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
436.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H30O2

[ Molecular Weight ]:
362.50

[ Flash Point ]:
171.9±23.0 °C

[ Exact Mass ]:
362.224579

[ PSA ]:
29.46000

[ LogP ]:
7.63

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.560

Related Compounds