DD-01050

A potent, noncompetitive TRPV1 antagonist that abrogates capsaicin and pH-evoked TRPV1 channel activity with submicromolar activity; preferentially inhibits TRPV1, showing marginal block of other neuronal receptors; inhibits capsaicin-evoked nerve activity in afferent fibers without affecting mechanically activated activity, attenuates carrageenan-induced paw inflammation, without affecting normal nociception in vivo; also decreases the cells in S/G2/M phases in prostate PC3 cells.

References 1. García-Martínez C, et al. J Pain. 2006 Oct;7(10):735-46. 2. Valero ML, et al. PLoS One. 2012;7(12):e51825. View Related Products by Target TRP Channel