Phenol,4-amino-2-[(diethylamino)methyl]-, hydrochloride (1:2)

Names

[ Name ]:
Phenol,4-amino-2-[(diethylamino)methyl]-, hydrochloride (1:2)

[Synonym ]:
4-AMINO-2-(DIETHYLAMINOMETHYL)PHENOL 2HCL
4-amino-2-(diethylaminomethyl)phenol dihydrochloride
3-Diethylaminomethyl-4-hydroxyaniline dihydrochloride
4-Amino-2-(diethylaminomethyl)phenol-dihydrochlorid

Biological Activity

[Description]:

AChE-IN-23 (compound 3h) is an acetylcholinesterase (AChE) inhibitor with an IC50 value of 48.3 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[References]

[1]. Martijn Constantijn de Koning, et al. Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase. Eur J Med Chem. 2018 Sep 5;157:151-160.

Chemical & Physical Properties

[ Boiling Point ]:
325.3ºC at 760 mmHg

[ Melting Point ]:
215-218ºC (dec.)(lit.)

[ Molecular Formula ]:
C₁₁H₂₀Cl₂N₂O

[ Molecular Weight ]:
267.19500

[ Flash Point ]:
150.5ºC

[ Exact Mass ]:
266.09500

[ PSA ]:
49.49000

[ LogP ]:
4.00140

MSDS

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Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-37/38-41

[ Safety Phrases ]:
S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2922299090

Synthetic Route

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Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%