Brilliant Green

Names

[ CAS No. ]:
633-03-4

[ Name ]:
Brilliant Green

[Synonym ]:
Brilliant Green
N-(4-{[4-(Diethylamino)phenyl](phenyl)methyliden}cyclohexa-2,5-dien-1-yliden)-N-ethylethanaminiumhydrogen-_sulfat
EINECS 211-190-1
4-{[4-(Diethylamino)phenyl](phenyl)methylene}-N,N-diethyl-2,5-cyclohexadien-1-iminium hydrogen sulfate
Brillant green
MFCD00011880
N-(4-{[4-(Diethylamino)phenyl](phenyl)methylene}-2,5-cyclohexadien-1-ylidene)-N-ethylethanaminium hydrogen sulfate
Brilliant Green G
EMERALD GREEN
4,4'-bis-diethylamino-tritylium,hydrogen sulfate
N-(4-{[4-(diethylamino)phenyl](phenyl)methylidene}cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium hydrogen sulfate
N-(4-{[4-(Diethylamino)phenyl](phenyl)methylene}cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium hydrogen sulfate
Diamond Green G
Malachite Green G

Biological Activity

[Description]:

Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Nandi BK, et al. Adsorption characteristics of brilliant green dye on kaolin. J Hazard Mater. 2009 Jan 15;161(1):387-95.

[2]. Narat JK. BRILLIANT GREEN: A CLINICAL STUDY OF ITS VALUE AS A LOCAL ANTISEPTIC. Ann Surg. 1931 Dec;94(6):1007-12.

Chemical & Physical Properties

[ Melting Point ]:
210 °C (dec.)(lit.)

[ Molecular Formula ]:
C₂₇H₃₄N₂O₄S

[ Molecular Weight ]:
482.635

[ Exact Mass ]:
482.223938

[ PSA ]:
92.29000

[ LogP ]:
6.48360

[ Water Solubility ]:
100 G/L (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP6825000

CAS REGISTRY NUMBER :: 633-03-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C27-H33-N2.H-O4-S

MOLECULAR WEIGHT :: 482.69

WISWESSER LINE NOTATION :: L6Y DYJ AUYR&R DN2&2& DUK2&2 &Q &S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema Gastrointestinal - necrotic changes Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 104 mg/m3/6W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 100 ug/L

REFERENCE :: VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications. Volume(issue)/page/year: #542-84 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2187 No. of Facilities: 581 (estimated) No. of Industries: 12 No. of Occupations: 14 No. of Employees: 7268 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2187 No. of Facilities: 1486 (estimated) No. of Industries: 16 No. of Occupations: 22 No. of Employees: 43142 (estimated) No. of Female Employees: 29395 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
BP6825000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

DownStream

Articles

Removal of Brilliant Green from wastewater using conventional and ultrasonically prepared poly(acrylic acid) hydrogel loaded with kaolin clay: A comparative study.

Ultrason. Sonochem. 20(3) , 914-23, (2013)

The present work deals with the removal of Brilliant Green dye from wastewater using a poly(acrylic acid) hydrogel composite (PAA-K hydrogel) prepared by incorporation of kaoline clay. The composite h...

Determination of residues of three triphenylmethane dyes and their metabolites (malachite green, leuco malachite green, crystal violet, leuco crystal violet, and brilliant green) in aquaculture products by LC/MS/MS: first action 2012.25.

J. AOAC Int. 96(5) , 1152-7, (2013)

During the AOAC Annual Meeting held from September 30 to October 3, 2012 in Las Vegas, NV, the Expert Review Panel (ERP) on Veterinary Drug Residues reviewed data for the method for determination of r...

Macrophage-specific overexpression of interleukin-5 attenuates atherosclerosis in LDL receptor-deficient mice.

Gene Ther. 22 , 645-52, (2015)

Interleukin-5 (IL-5) increases the secretion of natural T15/EO6 IgM antibodies that inhibit the uptake of oxidized low-density lipoprotein (LDL) by macrophages. This study aimed to determine whether m...