1,4-Anthracenedione

1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

DNA/RNA synthesis[1]

1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4[1]. 1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal[1]. 1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM. Cell Viability Assay[1] Cell Line: L1210 cells Concentration: 2.62 nM-1.6 μM Incubation Time: 4 days Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.