Brofaromine

Names

[ CAS No. ]:
63638-91-5

[ Name ]:
Brofaromine

[Synonym ]:
Brodimoprimum
Brofaromine
Hyprim
Bromdimoprim
Brodimoprima
Brodimoprime
brodimoprim

Biological Activity

[Description]:

Brofaromine is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 μM for MAO-A.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

Natural Products >> Alkaloid

[Target]

IC50: 0.2 μM (MAO-A)[1]

[In Vitro]

In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01 μM to 0.1 μM[1].

[References]

[1]. Boland A, et al. Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition. Br J Pharmacol. 2002 Feb;135(3):713-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.386g/cm3

[ Boiling Point ]:
404ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₆BrNO₂

[ Molecular Weight ]:
310.18600

[ Flash Point ]:
198.2ºC

[ Exact Mass ]:
309.03600

[ PSA ]:
34.40000

[ LogP ]:
3.99970

[ Index of Refraction ]:
1.588

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%