Coniferyl ferulate

Names

[ Name ]:
Coniferyl ferulate

[Synonym ]:
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propen-1-yl (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, (2E)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-yl ester, (2E)-
[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, 3-(4-hydroxy-3-methoxyphenyl)-2-propenyl ester

Biological Activity

[Description]:

Coniferyl ferulate, a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis, reverses multidrug resistance and downregulates P-glycoprotein. Coniferyl ferulate shows strong inhibition of human placental GST with an IC50 of 0.3 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[Target]

Glutathione S-transferase[1] P-glycoprotein[1]

[References]

[1]. Chen C, et al. Coniferyl Ferulate, a Strong Inhibitor of Glutathione S-Transferase Isolated from Radix Angelicae sinensis, Reverses Multidrug Resistance and Downregulates P-Glycoprotein. Evid Based Complement Alternat Med. 2013;2013:639083.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
570.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀O₆

[ Molecular Weight ]:
356.369

[ Flash Point ]:
202.8±23.6 °C

[ Exact Mass ]:
356.125977

[ PSA ]:
85.22000

[ LogP ]:
2.78

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Storage condition ]:
2-8C

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%