Ocrelizumab

Names

[ Name ]:
Ocrelizumab

[Synonym ]:
Monoclonal antibody Pro70769
Pro-70769
Pro70769
Rhumab 2H7

Biological Activity

[Description]:

Ocrelizumab is an anti-CD20 antibody that depletes circulating immature and mature B cells but spares CD20-negative plasma cells. The effector mechanisms of Ocrelizumab are complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity. Ocrelizumab is the first monoclonal antibody for secondary primary progressive multiple sclerosis (PPMS)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[References]

[1]. Mulero P, et al. Ocrelizumab: a new milestone in multiple sclerosis therapy. Ther Adv Neurol Disord. 2018 May 10;11:1756286418773025.

Chemical & Physical Properties

No Any Chemical & Physical Properties