Trichothec-9-en-8-one,12,13-epoxy-4-[[(2Z)-1-oxo-2-butenyl]oxy]-, (4b)-
Names
[ CAS No. ]:
6379-69-7
[ Name ]:
Trichothec-9-en-8-one,12,13-epoxy-4-[[(2Z)-1-oxo-2-butenyl]oxy]-, (4b)-
[Synonym ]:
trichothecin
Trichothecine
Trichothec-9-en-8-one,12,13-epoxy-4-hydroxy-,crotonate
Wln: T4 C5 I6 C6 A B 2cg N bo ho jutj D1 eov1U2 K1 N1
Chemical & Physical Properties
[ Density]:
1.241g/cm3
[ Boiling Point ]:
451.179ºC at 760 mmHg
[ Molecular Formula ]:
C19H24O5
[ Molecular Weight ]:
332.39100
[ Flash Point ]:
234.248ºC
[ Exact Mass ]:
332.16200
[ PSA ]:
65.13000
[ LogP ]:
2.34610
[ Index of Refraction ]:
1.562
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YD0175000
- CHEMICAL NAME :
- Trichothecin
- CAS REGISTRY NUMBER :
- 6379-69-7
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C19-H24-O5
- MOLECULAR WEIGHT :
- 332.43
- WISWESSER LINE NOTATION :
- T4 C5 I6 C6 A B 2CG N BO HO JUTJ D1 EOV1U2 K1 N1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947- Volume(issue)/page/year: 12,213,1955
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,182,1981 *** REVIEWS *** TOXICOLOGY REVIEW NUREA8 Nutrition Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1942- Volume(issue)/page/year: 31,169,1973
Safety Information
[ Hazard Codes ]:
T+
[ Risk Phrases ]:
26/27/28-36/37/38
[ RIDADR ]:
UN 3172
[ RTECS ]:
YD0175000
[ Packaging Group ]:
I
[ Hazard Class ]:
6.1(a)