KKII5

Names

[ CAS No. ]:
6381-55-1

[ Name ]:
KKII5

[Synonym ]:
4,6-diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione
HMS558F13
HMS2663P05

Biological Activity

[Description]:

KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

IC50: 19 μM (LOX-1)[1]


[In Vitro]

KKII5 与腔体的 HIS499 相互作用，通过在分子的苯环和 HIS499 的咪唑环之间形成一个 π-π 堆叠相互作用[1]。 KKII5 (100 μM) 对脂质过氧化有明显抑制作用，抑制率达 98% [1]。

[References]

[1]. Georgiou N, et al. Thiocarbohydrazone and Chalcone-Derived 3,4-Dihydropyrimidinethione as Lipid Peroxidation and Soybean Lipoxygenase Inhibitors. ACS Omega. 2023 Mar 21;8(13):11966-11977.  

Chemical & Physical Properties

[ Melting Point ]:
181-183ºC

[ Molecular Formula ]:
C16H14N2S

[ Molecular Weight ]:
266.36

[ Exact Mass ]:
266.08800

[ PSA ]:
56.15000

[ LogP ]:
3.90410

Safety Information

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36/37/39