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VUF 5681 dihydrobromide

Names

[ CAS No. ]:
639089-06-8

[ Name ]:
VUF 5681 dihydrobromide

[Synonym ]:
Pentoxyresorufin
VUF 5681 dihydrobromide

Biological Activity

[Description]:

VUF 5681 dihydrobromide is a neutral antagonist of histamine H3 receptor. VUF 5681 dihydrobromide also has partial agonist function of H3 receptor. VUF 5681 dihydrobromide blocks the effects of Thioperamide (HY-12206). VUF 5681 dihydrobromide is used in central nervous system disease research[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H3 receptor


[References]

[1]. Moreno-Delgado D, et al. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23.  

[2]. Baker JG. Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. BMC Pharmacol. 2008 Jun 6;8:9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H21Br2N3

[ Molecular Weight ]:
355.11

[ Exact Mass ]:
353.01000

[ PSA ]:
40.71000

[ LogP ]:
3.97700

Related Compounds