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N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide

Names

[ CAS No. ]:
639089-73-9

[ Name ]:
N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide

[Synonym ]:
Propanamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-
N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]propanamide

Biological Activity

[Description]:

VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[References]

[1]. Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27.  

[2]. Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C22H28N8OS

[ Molecular Weight ]:
452.576

[ Exact Mass ]:
452.210663

[ LogP ]:
1.34

[ Index of Refraction ]:
1.684

Related Compounds