N-Desmethyl Pimavanserin

Names

[ Name ]:
N-Desmethyl Pimavanserin

Biological Activity

[Description]:

N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.

[In Vitro]

The mean plasma half-lives for Pimavanserin and its metabolite N-Desmethyl Pimavanserin (AC-279) are 57 hours and 200 hours, respectively.

[References]

[1]. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₂FN₃O₂

[ Molecular Weight ]:
413.53

N-Desmethyl Pimavanserin

Names

Biological Activity

Chemical & Physical Properties

Related Compounds