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Valopicitabine

Names

[ CAS No. ]:
640281-90-9

[ Name ]:
Valopicitabine

[Synonym ]:
Valopicitabine [INN]
NMC-283
NM-283
val-mCyd
Valopicitabine
UNII-I2T0B5G94M

Biological Activity

[Description]:

Valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine, acts as a promising antiviral agent for reasearch of chronic HCV infection[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HCV[1]


[In Vivo]

Valopicitabine (NM 283) has potent antiviral activity against chronic hepatitis C virus genotype-1 in the chimpanzee[1]. Valopicitabine exhibits moderate Cmax (3.62 ug/mL) and terminal elimination half-lives (T1/2 0.64 h) following oral administration (100 mg/kg) in Sprague-Dawley rats[2].

[References]

[1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70.

[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H24N4O6

[ Molecular Weight ]:
356.37400

[ Exact Mass ]:
356.17000

[ PSA ]:
162.92000

Related Compounds